Intramammary infusion of tannin-chitosan hydrogels for prevention or treatment of bovine mastitis

PI: Christian Krueger

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Krueger is a research project manager in the Department of Animal and Dairy Science at UW–Madison.

Bovine mastitis is the leading cause of infections in Wisconsin dairy herds and worldwide. Klebsiella pneumoniae and Streptococcus uberis are pathogens associated with increased incidence of clinical mastitis in Wisconsin dairy cows. Traditional antibiotic therapies to control bacteria associated with bovine mastitis have low efficacy against K. pneumoniae causing longer milk discard and greater economic loss to farmers. Therefore, it is imperative to develop alternatives to control clinical mastitis and contain the spread of the pathogen in Wisconsin dairy herds. Krueger’s team previously discovered that tannins and chitosan can be combined to create novel composite hydrogels with antimicrobial properties . This patented invention was assigned to the Wisconsin Alumni Research Foundation and is currently available for licensing. The primary objectives of this project are to conduct in vitro and in vivo trials to demonstrate: 1) safety of intramammary infusion and 2) antimicrobial efficacy of the tannin-chitosan hydrogels, with and without the inclusion of anti-microbial peptides. Outcomes of this project include de-risking the technology to improve licensability and commercialization.

Hilario Mantovani